Protease-activated receptors – biology and role in cancer
نویسندگان
چکیده
منابع مشابه
Protease-activated receptors in hemostasis.
Protease signaling in cells elicits multiple physiologically important responses via protease-activated receptors (PARs). There are 4 members of this family of G-protein-coupled receptors (PAR1-4). PARs are activated by proteolysis of the N terminus to reveal a tethered ligand. The rate-limiting step of PAR signaling is determined by the efficiency of proteolysis of the N terminus, which is reg...
متن کاملProtease-activated receptors and itch.
Protease-activated receptors (PARs) have been implicated in a variety of physiological functions, as well as somatosensation and particularly itch and pain. Considerable attention has focused on PARs following the finding they are upregulated in the skin of atopic dermatitis patients. The present review focuses on recent studies showing that PARs are critically involved in itch and sensitizatio...
متن کاملHEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia
Sepsis is associated with a systemic activation of coagulation and an excessive inflammatory response. Anticoagulants have been shown to inhibit both coagulation and inflammation in sepsis. In this study, we used both genetic and pharmacologic approaches to analyze the role of tissue factor and protease-activated receptors in coagulation and inflammation in a mouse endotoxemia model. We used mi...
متن کاملHEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis
Procoagulant activity on tumor cells can enhance their ability to spread via the circulation to colonize distant organs. Toward defining the relative importance of the main host responses to coagulation for hematogenous metastasis, we examined lung metastases after intravenous injection of melanoma cells in NfE2 / mice, which have virtually no circulating platelets; Par4 / mice, which have plat...
متن کاملHEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Roles of protease-activated receptors in a mouse model of endotoxemia
Endotoxemia is often associated with extreme inflammatory responses and disseminated intravascular coagulation. Protease-activated receptors (PARs) mediate cellular responses to coagulation proteases, including platelet activation and endothelial cell reactions predicted to promote inflammation. These observations suggested that PAR activation by coagulation proteases generated in the setting o...
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ژورنال
عنوان ژورنال: Postępy Higieny i Medycyny Doświadczalnej
سال: 2016
ISSN: 1732-2693
DOI: 10.5604/17322693.1209209